Automatic classification of high-resolution mass spectrometry data has increasing potential to support physicians in diagnosis of diseases like cancer. The proteomic data exhibit variations among different disease states. A precise and reliable classification of mass spectra is essential for a successful diagnosis and treatment. The underlying process to obtain such reliable classification results is a crucial point. In this paper such a method is explained and a corresponding semi automatic parameterization procedure is derived. Thereby a simple straightforward classification procedure to assign mass spectra to a particular disease state is derived. The method is based on an initial preprocessing stage of the whole set of spectra followed by the bi-orthogonal discrete wavelet transform (DWT) for feature extraction. The approximation coefficients calculated from the scaling function exhibit a high peak pattern matching property and feature a denoising of the spectrum. The discriminating coefficients, selected by the Kolmogorov–Smirnov test are finally used as features for training and testing a support vector machine with both a linear and a radial basis kernel. For comparison the peak areas obtained with the it ClinProt-System1 [33] were analyzed using the same support vector machines. The introduced approach was evaluated on clinical MALDI-MS data sets with two classes each originating from cancer studies. The cross validated error rates using the wavelet coefficients where better than those obtained from the peak areas2. 相似文献
In the framework of P systems, it is known that the construction of exponential number of objects in polynomial time is not
enough to efficiently solve NP-complete problems. Nonetheless, it could be sufficient to create an exponential number of membranes in polynomial time. Working
with P systems whose membrane structure does not increase in size, it is known that it is not possible to solve computationally
hard problems (unless P = NP), basically due to the impossibility of constructing exponential number of membranes, in polynomial time, using only evolution,
communication and dissolution rules. In this paper we show how a family of recognizer tissue P systems with symport/antiport
rules which solves a decision problem can be efficiently simulated by a family of basic recognizer P systems solving the same
problem. This simulation allows us to transfer the result about the limitations in computational power, from the model of
basic cell-like P systems to this kind of tissue-like P systems. 相似文献
We present calculations of the tunneling density of states in an anisotropically paired superconductor for two different sample geometries: a semi-infinite system with a single specular wall, and a slab of finite thickness and infinite lateral extent. In both cases we are interested in the effects of surface pair breaking on the tunneling spectrum. We take the stable bulk phase to be of dx2–y2 symmetry. Our calculations are performed within two different band structure environments: an isotropic cylindrical Fermi surface with a bulk order parameter of the form k
x2
–k
y2
, and a nontrivial tight-binding Fermi surface with the order parameter structure coming from an antiferromagnetic spin-fluctuation model. In each case we find additional structures in the energy spectrum coming from the surface layer. These structures are sensitive to the orientation of the surface with respect to the crystal lattice, and have their origins in the detailed form of the momentum and spatial dependence of the order parameter. By means of tunneling spectroscopy, one can obtain information on both the anisotropy of the energy gap, ¦(p)¦, as well as on the phase of the order parameter, (p) = ¦(p)¦ ei(p). 相似文献
The world has been challenged since late 2019 by COVID-19. Higher education institutions have faced various challenges in adapting online education to control the pandemic spread of COVID-19. The present study aims to conduct a survey study through the interview and scrutinizing the literature to find the key challenges. Subsequently, an integrated MCDM framework, including Stepwise Weight Assessment Ratio Analysis (SWARA) and Multiple Objective Optimization based on Ratio Analysis plus Full Multiplicative Form (MULTIMOORA), is developed. The SWARA procedure is applied to the analysis and assesses the challenges to adapt the online education during the COVID-19 outbreak, and the MULTIMOORA approach is utilized to rank the higher education institutions on hesitant fuzzy sets. Further, an illustrative case study is considered to express the proposed idea's feasibility and efficacy in real-world decision-making. Finally, the obtained result is compared with other existing approaches, confirming the proposed framework's strength and steadiness. The identified challenges were systemic, pedagogical, and psychological challenges, while the analysis results found that the pedagogical challenges, including the lack of experience and student engagement, were the main essential challenges to adapting online education in higher education institutions during the COVID-19 outbreak.
Autonomous Robots - We propose a simple yet effective set of local control rules to make a small group of “herder agents” collect and contain in a desired region a large ensemble of... 相似文献
Journal of Mathematical Imaging and Vision - The paper proposes a polygonal approximation for closed 4-paths obtained from standard contour following under 4-connectivity. Those 4-contours generate... 相似文献
When interval-grouped data are available, the classical Parzen–Rosenblatt kernel density estimator has to be modified to get a computable and useful approach in this context. The new nonparametric grouped data estimator needs of the choice of a smoothing parameter. In this paper, two different bandwidth selectors for this estimator are analyzed. A plug-in bandwidth selector is proposed and its relative rate of convergence obtained. Additionally, a bootstrap algorithm to select the bandwidth in this framework is designed. This method is easy to implement and does not require Monte Carlo. Both proposals are compared through simulations in different scenarios. It is observed that when the sample size is medium or large and grouping is not heavy, both bandwidth selection methods have a similar and good performance. However, when the sample size is large and under heavy grouping scenarios, the bootstrap bandwidth selector leads to better results. 相似文献